Preheat the air fryer to 400°F (200°C) for 3 minutes.
In a small bowl, mix the olive oil, garlic powder, paprika, salt, and black pepper.
Brush both sides of the frozen tilapia fillets with the olive oil mixture.
Place the seasoned frozen tilapia fillets in the air fryer basket in a single layer, ensuring they do not overlap.
Cook the tilapia in the air fryer at 400°F (200°C) for 12 minutes, flipping the fillets halfway through the cooking time.
Check the internal temperature of the fish with a meat thermometer; it should reach 145°F (63°C) and the fish should flake easily with a fork.
Remove the tilapia from the air fryer and serve immediately with lemon wedges.